:%g!/\< \(STRING\|VALUE\)\>/d Explanation :%g Range to search. %g means the complete file ! Negotiation. Can be used to negate the regex \< \(STRING\|VALUE\)\ regular expression (regex). Can be anything /d command to execute with each line found. d means delete Example used :%g/INSERT INTO `table` VALUES>/d This command deletes ALL lines with INSERT INTO `table` […]